Research Field
Regulatory Code
Dynamic genome architecture integrates genetic information and environmental signals to control gene activity.
Description
The three-dimensional organization of the genome plays a central role in controlling gene activity while remaining highly responsive to developmental and environmental signals. This research area investigates how the regulatory information encoded in nucleic acids establishes genome architecture, how chromatin senses and responds to external and internal cues, and how these processes shape gene expression.
A major focus is understanding the relationship between genome folding and genome activity. The research explores how DNA sequences, epigenetic features, non-coding RNAs, and associated proteins contribute to the formation and dynamics of genome architecture. It further examines how chromatin functions as a sensor of environmental and metabolic signals and how these inputs are translated into changes in gene regulation. Using dynamic biological systems, including development, metabolic sensing, and infection, the project aims to establish causal links between genome organization and gene expression and to uncover the principles that coordinate cellular adaptation, identity, and homeostasis.
